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已知β-2受体拮抗剂特布他林(terbutaline)具有阻止炎症介质诱导的毛细血管蛋白漏出作用和增加内毒素休克大鼠的存活率。最近有报道指出,在羊模型实验中,如于内毒素之前给与特布他林,可使内毒素对肺顺应性、肺动脉压和氧传递作用比仅给内毒素的对照组明显减轻。作者取羊14只,麻醉后经静注大肠杆菌内毒素10μg/kg,15分钟。30分钟后,将动物分成两组,每组各7只,A组静注特布他林20 μg/kg/h,共4小时,B组7只作为对照,以研究特布他林对血流动力学和气体交换
Terbutaline, a beta-2 receptor antagonist, is known to have the ability to prevent the inflammatory mediator-induced capillary protein leakage and increase the survival rate of endotoxic shock rats. Recently, it has been reported that in the sheep model experiment, administration of terbutaline to endotoxin can significantly reduce the effects of endotoxin on pulmonary compliance, pulmonary arterial pressure and oxygen delivery compared with the endotoxin-only control group. The author took 14 sheep, after anesthesia by E. coli endotoxin 10μg / kg, 15 minutes. Thirty minutes later, the animals were divided into two groups of seven rats each, group A received intravenous injection of terbutaline 20 μg / kg / h for 4 hours, and group B received 7 rats as control to study the effect of terbutaline on blood Flow dynamics and gas exchange