论文部分内容阅读
目的探讨腹水中高荧光强度细胞(HF-BF)临床应用价值。方法应用XT-4000i全血细胞分析仪体液模式分析760例肝硬化和肝癌患者腹水细胞中HF-BF绝对值和比率,分别比较其在肝硬化、肝癌组中的情况,以及不同的Child-Pugh分级、肝癌临床分期以及腹腔感染对结果的影响。结果肝癌组和肝硬化组的HF-BF绝对值分别为0.031(0.011,0.082)×10~9/L、0.026(0.011,0.052)×10~9/L,比率分别为8.6。(2.90,25.70)%、6.90(3.00,11.90)%,肝癌组HF-BF绝对值和比率均明显高于肝硬化组,差异均有统计学意义(P=0.000,P=0.022)。且不同Child-Pugh分级的肝癌患者HF-BF绝对值和比率均有统计学意义(P=0.000)。而不同Child-Pugh分级的肝硬化患者中仅HF-BF比率的差异有统计学意义(P=0.014)。肝硬化腹水合并腹腔感染患者的HF-BF的比率和绝对值显著高于无腹腔感染患者(P=0.003,P=0.009),肝癌组合并腹腔感染患者的HF-BF的比率显著高于无腹腔感染患者(P=0.040)。肝硬化合并腹腔感染患者和肝癌组合并腹腔感染患者腹水的HF-BF的比率和绝对值间差异无统计学意义(P>0.05)。不同临床分期的肝癌患者HF-BF的比率和绝对值的差异无统计学意义(P>0.05)。结论通过体液模式HF-BF的分析,有助于对腹水良恶性的判断,同时提示患者是否有腹腔感染,其中HF-BF的比率意义更明显。
Objective To investigate the clinical value of high-intensity fluorescent cells (HF-BF) in ascites. Methods The absolute value and ratio of HF-BF in ascites cells from 760 patients with cirrhosis and hepatocellular carcinoma were analyzed by XT-4000i whole blood cell analyzer. The absolute value and ratio of HF-BF in cirrhosis and hepatocellular carcinoma were compared with those in Child-Pugh classification , Clinical stage of liver cancer and abdominal infection on the results. Results The absolute values of HF-BF in liver cancer group and cirrhosis group were 0.031 (0.011,0.082) × 10 ~ 9 / L and 0.026 (0.011,0.052) × 10 ~ 9 / L, respectively. (2.90,25.70)% and 6.90 (3.00,11.90)% respectively. The absolute value and ratio of HF-BF in liver cancer group were significantly higher than those in cirrhosis group (P = 0.000, P = 0.022). The absolute value and ratio of HF-BF in patients with different Child-Pugh grades were statistically significant (P = 0.000). However, only the differences of HF-BF rates in patients with different Child-Pugh grades of liver cirrhosis were statistically significant (P = 0.014). The ratio and absolute value of HF-BF in cirrhotic patients with ascitic fluid infection were significantly higher than those without abdominal infection (P = 0.003, P = 0.009). The rate of HF-BF in patients with hepatocellular carcinoma combined with abdominal infection was significantly higher than that without abdominal cavity Infected patients (P = 0.040). The ratio and absolute value of HF-BF in patients with cirrhosis complicated with abdominal infection and hepatocellular carcinoma complicated with ascites had no significant difference (P> 0.05). There was no significant difference in the ratio and absolute value of HF-BF among patients with different clinical stages of liver cancer (P> 0.05). Conclusion The analysis of HF-BF in bodily fluid model is helpful to judge the benign and malignant ascites and to indicate whether the patient has abdominal infection. The significance of HF-BF ratio is more obvious.