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急性冠状动脉综合征(ACS)具有很高的发病率和死亡率,严重威胁人类健康。目前已经证实易损斑块的破裂、血小板聚集和继发血栓形成造成冠状动脉急性严重狭窄或闭塞是ACS的主要发病机制。易损斑块的存在是发生ACS的病理基础,而易损斑块的破裂则是ACS发生的始动环节。早期发现易损斑块,及时进行干预,对降低ACS的发病率和死亡率,具有极其重要的临床意义。血清中一些标记物如C反应蛋白、妊娠相关蛋白A等对易损斑块具有早期诊断价值,有助于早期发现ACS高危人群及将来发生的急性心血管事件。作者就检测易损斑块的标志物的研究进展作一综述。
Acute coronary syndrome (ACS) has a high morbidity and mortality and poses a serious threat to human health. It has been confirmed that the rupture of vulnerable plaque, platelet aggregation and secondary thrombosis resulting in severe acute coronary artery stenosis or occlusion is the main pathogenesis of ACS. The presence of vulnerable plaque is the pathological basis for the occurrence of ACS, and the rupture of vulnerable plaque is the beginning of ACS. Early detection of vulnerable plaque, timely intervention, to reduce the incidence of ACS and mortality, has extremely important clinical significance. Serum markers such as C-reactive protein, pregnancy-related protein A and other early diagnosis of vulnerable plaque value is helpful to early detection of ACS high-risk groups and future occurrence of acute cardiovascular events. The authors reviewed the research progress of markers for the detection of vulnerable plaque.