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目的探讨原发性乳腺神经内分泌癌的诊断和治疗策略。方法结合文献对上海市第八人民医院普外科自1980年至今收治的13例原发性乳腺神经内分泌癌的分类、流行病学、诊断和治疗方法等进行分析。结果13例中实体型原发性乳腺神经内分泌癌4例,小细胞型原发性乳腺神经内分泌癌5例,大细胞型原发性乳腺神经内分泌癌4,皆无腋窝淋巴结转移,总的5年无病存活率为76.9%(10/13),存活率为84.6%(11/13),病死率为15.4%(2/13)。结论原发性乳腺神经内分泌癌的影像学诊断比较困难,诊断上的金标准是组织活检。在治疗上,参考乳腺浸润性导管癌的治疗策略对其治疗可获得较满意效果。
Objective To investigate the diagnosis and treatment of primary breast neuroendocrine carcinoma. Methods According to the literature, the classification, epidemiology, diagnosis and treatment of 13 cases of primary breast neuroendocrine carcinoma admitted to general surgery department of Shanghai Eighth People ’s Hospital from 1980 to now were analyzed. Results In 13 cases, 4 cases of solid primary breast neuroendocrine carcinoma, 5 cases of small cell type primary breast neuroendocrine carcinoma, 4 cases of large cell type primary breast neuroendocrine carcinoma, all had no axillary lymph node metastasis, with a total of 5 The disease-free survival rate was 76.9% (10/13), the survival rate was 84.6% (11/13) and the case fatality rate was 15.4% (2/13). Conclusion Imaging diagnosis of primary breast neuroendocrine carcinoma is more difficult. The gold standard in diagnosis is tissue biopsy. In the treatment, refer to the treatment of breast invasive ductal carcinoma treatment strategies for its treatment can be more satisfactory results.