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用原位杂交的方法对结直肠癌组织和结直肠正常粘膜组织内人乳头状瘤病毒 16 / 18(HPV16 / 18)感染进行了检测 ,探讨HPV16 / 18与大肠癌的发生及组织学分化程度等的关系。结果发现 ,30例结直肠癌组织HPV16 / 18阳性者 19例 ,阳性率为 6 3 3% ;30例结直肠正常组织HPV16 / 18均为阴性 ,两者之间比较差异非常显著(P <0 0 1) ;HPV16 / 18感染和患者性别、年龄、肿块的大小、浸润深度、原发部位、组织学分化程度及是否有淋巴转移均无关。HPV16 / 18病毒不仅在鳞状上皮中增生繁殖 ,在腺上皮细胞中也能增生繁殖 ;并且HPV16 / 18感染参与了结直肠癌的发生过程。
In situ hybridization was used to detect the HPV16 / 18 infection in colorectal cancer tissue and normal colorectal mucosa, and to investigate the occurrence and histological differentiation of HPV16 / 18 and colorectal cancer And so on. Results The positive rate of HPV16 / 18 in 30 colorectal cancer tissues was 63.3%. The positive rate of HPV16 / 18 in 30 colorectal tissues was negative, with significant difference (P <0 HPV16 / 18 infection had no correlation with gender, age, size of tumor, depth of invasion, primary site, histological differentiation and lymph node metastasis. The HPV16 / 18 virus not only proliferates in the squamous epithelium, but also proliferates in the glandular epithelial cells. HPV16 / 18 infection is involved in the carcinogenesis of colorectal cancer.