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目的:研究谷胱甘肽S-转移酶P1(GSTP1)、上皮钙粘蛋白(E-cadherin)在垂体腺瘤中的表达及临床意义。方法:应用免疫组化SP染色法检测30例侵袭性垂体腺瘤与30例非侵袭性垂体腺瘤中GSTP1、E-cadherin的表达。结果:GSTP1在侵袭性垂体腺瘤中的表达较非侵袭性垂体腺瘤显著降低(P<0.05);E-cadherin在侵袭性垂体腺瘤中的表达较非侵袭性垂体腺瘤显著降低(P<0.05);GSTP1、E-cadherin在垂体腺瘤中的表达呈正相关(r=0.82,P<0.05)。结论:GSTP1、E-cadherin在垂体腺瘤中的表达与肿瘤侵袭程度显著相关,两者联合检测有助于判断垂体腺瘤侵袭性及预后。
Objective: To study the expression and clinical significance of glutathione S-transferase P1 (GSTP1) and E-cadherin in pituitary adenoma. Methods: The expression of GSTP1 and E-cadherin in 30 cases of invasive pituitary adenomas and 30 cases of non-invasive pituitary adenomas were detected by SP immunohistochemistry. Results: The expression of GSTP1 in invasive pituitary adenomas was significantly lower than that in non-invasive pituitary adenomas (P <0.05). The expression of E-cadherin in invasive pituitary adenomas was significantly lower than that in non-invasive pituitary adenomas (P <0.05). The expression of GSTP1 and E-cadherin in pituitary adenomas was positively correlated (r = 0.82, P <0.05). Conclusion: The expression of GSTP1 and E-cadherin in pituitary adenomas is significantly correlated with the degree of tumor invasion. The combined detection of GSTP1 and E-cadherin may be helpful to evaluate the invasiveness and prognosis of pituitary adenomas.