目的:了解深圳地区不同年龄段和不同生殖道疾病妇女高危型HPV感染状况。方法:应用第2代杂交捕获信号放大系统(HC蛳Ⅱ)对2002年4月—11月到我院就诊和普查的1 898例患者进行HPV检测,检测13种高危型HPV DNA。结果:不同年龄段HPV检出率差异有显著性意义(χ2=12.09,P =0.017);≤20岁,21岁~ 25岁,26岁~ 30岁,30岁~ 40岁和≥40岁组的HPV患病率分别为34.8 %,29.2 %,22.6 %,26.2 %和24.2 %,总的患病率为26.6 %。不同生殖道疾病(阴道炎、宫颈炎、尖锐湿疣和≥CINI)和正常对照组比较可见尖锐湿疣和≥CINI的HPV检出率差异有显著性意义(P<0.005)。结论:>30岁的HPV检出率为25.9 %,不同生殖道疾病的HPV检出率不同,与尖锐湿疣与宫颈病变的发病关系密切。 OBJECTIVE: To understand the prevalence of high-risk HPV in women of different genital diseases and genital diseases in Shenzhen area. Methods: The HCG Ⅱ was used to detect HPV in 1 898 patients who visited our hospital from April to November in 2002 and 13 censuses were performed to detect 13 high-risk HPV DNA. Results: The detection rate of HPV in different age groups was significantly different (χ2 = 12.09, P = 0.017); ≤20 years old, 21 years old to 25 years old, 26 years old to 30 years old, 30 years old to 40 years old and 40 years old The prevalence of HPV was 34.8%, 29.2%, 22.6%, 26.2% and 24.2%, respectively. The overall prevalence was 26.6%. The detection rate of HPV between condyloma acuminatum and ≥CINI was significantly different between different genital tract diseases (vaginitis, cervicitis, condyloma acuminata and ≥CINI) and the normal control group (P <0.005). Conclusion: The detection rate of HPV> 30 years old is 25.9%. The detection rate of HPV in different genital diseases is different, which is closely related to the incidence of genital warts and cervical lesions.