论文部分内容阅读
目的检测丙烯酰胺(ACR)接触工人血清神经元特异性烯醇化酶(NSE)水平,探讨NSE作为ACR接触早期生物标志物的意义。方法于2010年对某丙烯酰胺制造厂101名接触工人和37名非接触人员进行问卷调查和体检,采用电化学发光法检测血清NSE水平,比较接触组和对照组血清NSE水平,并分析其影响因素。结果与对照组人群血清NSE水平([4.38±1.28)μg/L]相比,接触组工人血清NSE([5.50±1.88)μg/L]升高,差异有统计学意义(P<0.05);接触组工人血清NSE水平与空气ACR、皮肤表面ACR水平呈正相关(P<0.01);多元线性回归分析显示,男性、皮肤ACR水平高和空气ACR水平高是血清NSE升高的危险因素,使用防护措施是保护因素。结论 ACR接触工人血清NSE升高,血清NSE水平可作为早期接触ACR的分子生物学标志物。
Objective To detect the level of serum neuron specific enolase (NSE) in workers exposed to acrylamide (ACR) and to explore the significance of NSE as an early biomarker of ACR exposure. Methods In 2010, 101 workers and 37 non-contact workers in an acrylamide factory were surveyed and examined. The level of serum NSE was detected by electrochemiluminescence. The serum levels of NSE in the contact group and the control group were compared and analyzed factor. Results Compared with the control group, serum NSE level in the exposed group was significantly higher than that in the control group ([4.38 ± 1.28] μg / L] [(5.50 ± 1.88) μg / L], and the difference was statistically significant (P <0.05). The level of serum NSE was positively correlated with air ACR and skin surface ACR in contact group (P <0.01). Multiple linear regression analysis showed that male ACR level and air ACR level were the risk factors for elevated serum NSE levels. Measures are protective factors. Conclusion Serum NSE in ACR exposed workers is elevated, serum NSE level may be used as a molecular biomarker for early exposure to ACR.