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5. ~(153)Sm EDTMP combined with endocrine therapy for treatment of prostatic cancer bone metastasis

~(153)Sm EDTMP combined with endocrine therapy for treatment of prostatic cancer bone metastasis

来源 :Asian Journal of Andrology | 被引量 : 0次 | 上传用户：rwteng

【摘 要】

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Objective: To evaluate the effect of samarium ethylenediamine methylene phosphoric acid (153Sm EDTMP) combined with endocrine therapy in treating painful bone m

【出 处】

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Asian Journal of Andrology

【发表日期】

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2003年01期

【关键词】

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EDTMP prostatic endocrine metastasis 

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Objective: To evaluate the effect of samarium ethylenediamine methylene phosphoric acid (153Sm EDTMP) combined with endocrine therapy in treating painful bone metastasis of prostate cancer. Methods: 27 patients with painful bone metastasis of prostate cancer were randomly divided into 2 groups: 14 patients were given a combination of 153Sm EDTMP (1110-1480 MBq) and endocrine therapy, while 13 patients (control) were treated only with endocrine therapy. Three months later, bone radionuclide imaging examination was performed. Results: In the treatment group the metastatic bone pain was relieved in 13/14 (92.9 %), which is slightly higher (P>0.05)than that of the controls (10/13, 76.9 %). The median time for the beginning of pain release was 4 days in the treatment group and 8 days in the controls (P<0.01). Moreover, the objective response rate of bony metastasis 3 months later was 85.7 % (12/14) in the treatment group, which is significantly higher (P<0.05) than that in the controls (6/13, 46.2 %). Conclusion: The addition of 153Sm EDTMP not only effectively relieves metastatic bone pain of prostate cancer, but also degrades the bone foci. Objective: To evaluate the effect of samarium ethylenediamine methylene phosphoric acid (153Sm EDTMP) combined with endocrine therapy in treating painful bone metastasis of prostate cancer. Methods: 27 patients with painful bone metastasis of prostate cancer were randomly divided into 2 groups: 14 patients were given a combination of 153Sm EDTMP (1110-1480 MBq) and endocrine therapy, while 13 patients (control) were treated only with endocrine therapy. Three months later, bone radionuclide imaging examination was performed. Results: In the treatment group the metastatic bone pain was relieved in 13/14 (92.9%), which is slightly higher (P> 0.05) than that of the controls (10/13, 76.9%). The median time for the beginning of pain release was 4 days in the treatment group and 8 days in the controls (P <0.01). Moreover, the objective response rate of bony metastasis 3 months later was 85.7% (12/14) in the treatment group, which was significantly higher that in the con trols (6/13, 46.2%). Conclusion: The addition of 153Sm EDTMP not only effectively relieves metastatic bone pain of prostate cancer, but also degrades the bone foci.

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