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目的 观察家兔视网膜缺血 -再灌注后视网膜结构的动态变化。方法 通过前房灌注加压至 16 .7k Pa,维持 1h,建立缺血模型 ,观察再灌注 2～ 14d内其结构变化及内层视网膜平均厚度的变化。结果 家兔视网膜在缺血 -再灌注后 2～ 14d内表现为神经细胞持续丢失 ,视网膜层次逐渐不清 ,萎缩、变薄。其中神经节细胞、神经纤维及视锥、视杆对缺血最敏感 ,外颗粒层次之 ,内颗粒层最能耐受缺血 -再灌注后的损伤。结论 视网膜缺血 -再灌注损伤是个持续性、进行性的损伤过程 ,与功能变化相一致
Objective To observe the dynamic changes of retinal structure after retinal ischemia-reperfusion in rabbits. Methods The anterior chamber perfusion pressure to 16.7k Pa, maintained for 1h, the establishment of ischemia model, observed within 2 ~ 14d after reperfusion its structural changes and the average thickness of the inner retina. Results Rabbit retina showed continuous loss of neurons within 2-14 days after ischemia-reperfusion, and the retinal layer gradually became unclear, atrophied and thinned. Among them, ganglion cells, nerve fibers and cones were the most sensitive to the ischemia, while the outer granular layer was the most resistant to ischemia-reperfusion injury. Conclusion Retinal ischemia-reperfusion injury is a persistent and progressive injury process that is consistent with functional changes