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双环磷酸酯是一类具有高活性的惊厥药物。虽然认为它为GABA拮抗剂,但至今仍不很清楚它对动物神经、肌肉、循环及呼吸系统的作用。我们采用静脉、腹腔、脑室给药以及电生理等方法观察了化合物[学名4-(1-氯-1-甲基-乙基)-2,6,7-三氧杂-1-磷双环(2,2,2)辛烷,简称(C1)P7BO]对整体动物、离体器官和在体器官的作用。 一、0.3mg/kg(C1)PTBO对螻蜍神经干、肌肉、神经—肌接头部位无明显直接作用。静脉注射(0.25mg/kg)对麻醉家兔的皮层诱发电位有明显抑制作用。对胫神经诱发电位有增
Bicyclic phosphates are a class of convulsant drugs with high activity. Although it is considered a GABA antagonist, its effect on the nerves, muscles, circulation and respiratory system in animals has not been known yet. The compounds [name of 4- (1-chloro-1-methyl-ethyl) -2,6,7-trioxa-1-phosphonobicyclo 2,2,2) octane, abbreviation (C1) P7BO] on the whole animal, isolated organ and organ function. One, 0.3mg / kg (C1) PTBO had no obvious direct effect on the trunk, muscle and nerve-muscle junction of Bufo bufo gargarizans. Intravenous injection (0.25 mg / kg) significantly inhibited the cortical evoked potentials in anesthetized rabbits. The tibial nerve evoked potentials increased