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Ku蛋白是DNA末端结合蛋白,最初它是作为自身抗原在多发性肌炎-硬皮病重叠综合征(scleroderma-polymyositis o-verlap syndrome)患者中被发现的,其命名是源于第1个患者前两个字母Ku[1]。Ku蛋白广泛存在于不同组织中,但其mR-NA含量在胸腺和淋巴细胞中更丰富。Ku蛋白能与DNA末端及
Ku protein is a DNA-terminal binding protein originally discovered as a self-antigen in patients with polymyositis-scleroderma-polymyositis o-verlap syndrome and is named after the first patient The first two letters Ku [1]. Ku protein is widely found in different tissues but its mR-NA content is more abundant in thymus and lymphocytes. Ku protein can interact with DNA ends