论文部分内容阅读
目的 研究影响产超广谱β-内酰胺酶（ESBLs）细菌医院感染的危险因素,预防医院感染暴发。方法 对1999年5月～2000年5月5所医院发生的由产ESBLs细菌导致的147例医院感染病例、42例对照病例,用单因素分析和非条件logistic回归作多因素分析。结果 多因素分析结果显示再次住院、三代头孢菌素应用>3 d、联合应用抗生素、喹喏酮类抗生素使用>3 d及给氧有显著意义;ICU、外三病区、新生儿病区、呼吸病区产ESBLs细菌的感染率显著高于其他病区;各种标本的检出率无明显差异。结论 产ESBLs菌株广泛存在于临床各科,应积极开展对该菌株的监测。特别是重点感染科室应严格进行环境消毒,控制三代头孢菌素和喹喏酮类药物的使用。
Objective To study the risk factors of nosocomial infection of extended-spectrum β-lactamases (ESBLs) bacteria and prevent outbreaks of nosocomial infections. Methods A total of 147 cases of nosocomial infections and 42 control cases caused by ESBLs-producing bacteria in 5 hospitals from May 1999 to May 2000 were analyzed by multivariate analysis with univariate analysis and non-conditional logistic regression. Results multivariate analysis showed that hospitalization again, the third generation of cephalosporins application> 3 d, combined antibiotics, use of quinolone antibiotics> 3 d and oxygen has significant significance; ICU, outside the three wards, neonatal ward, The infection rate of ESBLs-producing bacteria in respiratory ward was significantly higher than that in other wards; the detection rate of various kinds of specimens showed no significant difference. Conclusion ESBLs-producing strains are widely found in clinical departments and should be actively monitored. In particular, should focus on infection departments should be strictly disinfected the environment, control third-generation cephalosporins and the use of quinolone drugs.