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目的观察子宫内膜异位症合并不孕患者腹腔镜术后应用温肾活血方(WKPCP)联合虫类药治疗的临床疗效。方法 79例肾虚血瘀型子宫内膜异位症(EM)合并不孕患者行腹腔镜手术后随机分为两组:B组(45例)采用WKPCP治疗,从月经周期第5天开始服药,连续10d,服用3个月经周期;A组(34例)在此基础上加用虫类药治疗。比较两组术后盆腔疼痛改善总有效率、3个月时血清IL-2和IL-10的水平以及6个月内妊娠率和流产率。结果治疗后,A组盆腔疼痛改善总有效率和妊娠率均高于B组(82.4%vs.55.6%和44.1%vs.31.1%)(P<0.05),两组流产率相仿(P>0.05)。与治疗前相比,治疗后两组血清IL-2水平升高,IL-10水平降低(P<0.05),A组较B组变化更明显(P<0.05)。结论 WKPCP联合虫类药治疗腹腔镜术后肾虚血瘀型子宫内膜异位症合并不孕患者能改善盆腔疼痛症状,提高妊娠率。
Objective To observe the clinical effect of Wenshen Huoxue Decoction (WKPCP) combined with insecticide after laparoscopic surgery in infertility patients with endometriosis. Methods 79 patients with kidney deficiency and blood stasis type endometriosis (EM) complicated with infertility were randomly divided into two groups: group B (45 cases) treated with WKPCP, taking medication from day 5 of menstrual cycle, Continuous 10d, taking 3 menstrual cycle; A group (34 cases) on the basis of insecticide treatment. The total effective rate of pelvic pain was compared between the two groups. The level of serum IL-2 and IL-10 at 3 months and the pregnancy rate and abortion rate within 6 months were compared. Results After treatment, the total effective rate of pelvic pain and pregnancy rate in group A were significantly higher than those in group B (82.4% vs.55.6% and 44.1% vs.31.1%, P <0.05) ). Compared with those before treatment, serum IL-2 level and IL-10 level decreased after treatment in both groups (P <0.05), while changes in group A were more obvious than those in group B (P <0.05). Conclusion WKPCP combined with insecticide treatment of laparoscopic kidney deficiency and blood stasis type of endometriosis patients with infertility can improve pelvic pain symptoms and improve pregnancy rate.