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目的：为加深对影响鼻咽癌（ＮＰＣ）预后因素的认识。方法：采用流式细胞仪（ＦＣＭ）对４４例ＮＰＣ癌细胞核ＤＮＡ进行检测，发现二倍体肿瘤（ＤＴ）１０例，近二倍体肿瘤（ｎＤＴ）１７例，非整倍体肿瘤（ＡＴ）１７例；４４例中，颈淋巴结转移３５例，经放疗后３年追综观察，鼻咽局部复发和（或）远处转移２４例。将不同ＤＮＡ倍体的ＮＰＣ、颈淋巴结转移和预后进行相关性分析。结果：ＮＰＣＤＮＡ倍体与转移之颈淋巴结及其大小无关；ｎＤＴ和ＡＴＮＰＣ放疗后３年局部复发比率高于ＤＴＮＰＣ；无颈淋巴结转移ＮＰＣ，放疗后３年局部复发率与有颈淋巴结转移者无差别（Ｐ＞００５）；与无颈淋巴结转移ＮＰＣ相比，有颈淋巴结转移者放疗后３年更易发生远处转移（Ｐ＜００５）。结论：ＮＰＣＤＮＡ倍体与鼻咽局部预后关系较为密切，而颈部淋巴结情况则与远处转移与否有关。
Objective: To deepen the understanding of prognostic factors of nasopharyngeal carcinoma (NPC). Methods: The nuclear DNA of 44 NPC patients was detected by flow cytometry (FCM). Ten cases of diploid tumors (DT), 17 of nearly diploid (nDT) tumors, 17 of aneuploid tumors (AT) 17 cases; 44 cases, cervical lymph node metastasis in 35 cases, followed up 3 years after radiotherapy, nasopharyngeal local recurrence and (or) distant metastasis in 24 cases. The different DNA ploidy of NPC, cervical lymph node metastasis and prognosis were analyzed. Results: The NPCDNA ploidy had no relation with the metastasis of cervical lymph nodes and its size. The local recurrence rates of nDT and ATNPC three years after radiotherapy were higher than that of DTNPC. There was no difference between NPC with no lymph node metastasis and local recurrence after 3 years of radiotherapy (P> 0.05). Compared with NPC without metastasis, patients with cervical lymph node metastasis were more likely to have distant metastasis 3 years after radiotherapy (P <005). Conclusion: The NPCDNA ploidy has a close relationship with the local prognosis of nasopharynx, while the cervical lymph node metastasis is related to distant metastasis.