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以水杨酸甲酯为起始原料 ,经氯代、硝化等 8步反应合成 5 HT3 受体拮抗剂阿扎西隆 ,以化合物 (2 )计总收率为 45 % (文献〔6〕收率为 34 % ) ,其结构经IR ,1H NMR和MS确证
Starting from methyl salicylate, 5-HT3 receptor antagonist azatholone was synthesized by 8 steps of chlorination and nitration. The total yield of compound (2) was 45% (Reference [6] The rate was 34%), its structure confirmed by IR, 1H NMR and MS