那格列奈与二甲双胍的联合应用,不仅具备以上二者单独应用时的优点,而且还可获得二者协同作用所带来的更大益处。现综述如下:1那格列奈为氨基酸衍生物,那格列奈通过与β细胞膜上的ATP敏感性K+通道受体相结合并将其关闭,使细胞去极化,钙通道开放,钙内流,从而刺激胰岛素的分泌,降 The combined use of nateglinide and metformin not only offers the advantages of both of the above, but also benefits from the synergistic effect of the two. Now summarized as follows: 1 nateglinide amino acid derivatives, nateglinide through the ATP membrane with the beta-sensitive K + channel receptor and its closure, the cell depolarization, calcium channels open, calcium Flow, thus stimulating the secretion of insulin, down