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目的探讨硫酸镁和酚妥拉明联合治疗哮喘的疗效。方法 60例急性重度发作的哮喘患者随机分为两组,两组均按常规给予治疗包括抗感染:支气管扩张剂,糖皮质激素及补液纠正电解质酸碱平衡紊乱等,治疗组同时给予酚妥拉明和25%硫酸镁静脉滴注,观察两组疗效,并做对比分析。结果对照组用药48h内有效者10例,48h以上有效者16例,无效4例,有效率为86.7%。治疗组用药48h内有效者26例,48h以上有效者4例,有效率为100%。治疗组有效率显著高于对照组(P<0.05)。结论在常规疗法的基础上,加用硫酸镁和酚妥拉明,可提高治疗支气管哮喘的疗效。不良反应小,值得临床推广。
Objective To investigate the efficacy of magnesium sulfate and phentolamine in the treatment of asthma. Methods Sixty patients with acute severe seizures were randomly divided into two groups. Patients in both groups were given routine treatment including anti-infectives: bronchodilators, glucocorticoids and fluid replacement to correct electrolyte acid-base balance disorders. The treatment group was given phentolamine Ming and 25% magnesium sulfate intravenous infusion, observe the two groups of curative effect, and make comparative analysis. Results In the control group, 10 cases were effective in 48 hours, 16 cases were effective in 48 hours, 4 cases were ineffective, and the effective rate was 86.7%. In the treatment group, there were 26 cases effective within 48 hours, 4 cases effective more than 48 hours, the effective rate was 100%. The treatment group was significantly higher than the control group (P <0.05). Conclusion On the basis of conventional therapy, adding magnesium sulfate and phentolamine can improve the curative effect of treating bronchial asthma. Adverse reactions, it is worth clinical promotion.