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目的:分析6月龄以下婴儿川崎病冠状动脉病变的特点，探讨其转归及影响因素。方法:回顾性分析2015年10月至2020年2月首都儿科研究所附属儿童医院重症监护室及新生儿内科收治的61例川崎病婴儿[男34例，女24例，年龄2.2(1.7，3.1)个月]的临床资料。患儿病程1年冠状动脉n Z值仍≥2.5者定义为持续冠状动脉瘤。Cox回归分析冠状动脉病变转归的相关因素。n 结果:61例婴儿川崎病冠状动脉瘤发生率为52.5%(32/61)，发生于病程的5(4，8)d。随访547(399，782)d，8.2%(5/61)患儿为持续冠状动脉瘤。冠状动脉恢复正常时间为病程的20(12，82) d。Cox回归显示冠状动脉最大n Z值是冠状动脉恢复的独立相关因素(n HR＝0.451，95%n CI 0.293-0.694，n P<0.001)。受试者工作特征曲线分析显示冠状动脉最大n Z值预测持续冠状动脉瘤的最佳临界值为6.15(敏感度80.0%，特异度97.7%)。n 结论:6月龄以下婴儿川崎病冠状动脉瘤发生率高，冠状动脉最大n Z值是持续冠状动脉瘤的独立相关因素。n “,”Objective:To analyze the characteristics of coronary artery lesions in infants under 6 months of age with Kawasaki disease(KD), and to explore their regression and risk factors.Methods:The clinical data of 61 infants with KD[34 boys, 24 girls, aged 2.2 (1.7, 3.1) months] admitted to the department of critical care medicine and neonatology, Children′s Hospital, Capital Institute of Pediatrics from October 2015 to February 2020 were retrospectively analyzed.Persistent coronary artery aneurysm(CAA)was defined as the persistent enlargement of coronary arteries(coronary Z-score≥2.5)on echocardiograms at 12 months after KD onset.Cox proportional hazards mode was conducted to evaluate the potential risk factors of persistent CAA.Results:The incidence of CAA in 61 infants with KD was 52.5% (32/61) and occurred on 5 (4, 8)d of the disease course.During a follow-up of 547 (399, 782)d, five(8.2%, 5/61)infants satisfied the definition of persistent CAA.The median recovery time of CAA was 20 (12, 82)d after KD onset.Cox proportional hazards mode revealed that the maximal coronary Z-score was an independent factor of CAA regression(n HR=0.451, 95%n CI 0.293-0.694, n P<0.001). Receiver operating characteristic curve analysis showed that the best cutoff value of coronary Z-score for predicting persistent CAA was 6.15(sensitivity 80.0%, specificity 97.7%).n Conclusion:CAA is common in infants younger than 6 months with KD.The maximal coronary Z-score is an independent factor of persistent CAA.