目的检测慢性肺源性心脏病急性加重期和临床缓解期患者血浆D-二聚体(D-dimer)含量的变化,分析其临床意义。方法慢性肺源性心脏病急性加重期和临床缓解期患者及正常对照组各30例,以ELISA法测定血浆D-dimer含量。结果慢性肺源性心脏病患者急性加重期和临床缓解期血浆D-dimer含量分别为(2.62±0.91)、(2.16±0.78)μg/L,均较正常对照者的(1.74±0.63)μg/L明显增高,差异有统计学意义(P<0.05);而急性加重期血浆D-dimer含量也明显高于缓解期(P<0.05)。结论 D-dimer增高是慢性肺源性心脏病临床病理生理改变的结果,而且与疾病的严重程度有关。 Objective To detect the changes of plasma D-dimer in patients with acute exacerbation of chronic cor pulmonale and clinical remission, and to analyze its clinical significance. Methods Thirty patients with acute exacerbation of chronic cor pulmonale and those with clinical remission and 30 normal controls were enrolled in this study. Plasma D-dimer was measured by ELISA. Results The plasma levels of D-dimer in acute exacerbation and remission of patients with chronic cor pulmonale were (2.62 ± 0.91) and (2.16 ± 0.78) μg / L, respectively, which were significantly higher than those of the normal controls (1.74 ± 0.63) μg / L were significantly higher (P <0.05), while the content of D-dimer in acute exacerbation was also significantly higher than that in remission (P <0.05). Conclusion Increased D-dimer is the result of clinical pathophysiological changes of chronic cor pulmonale, and is related to the severity of the disease.