１９９４年Ｋａｍｂ等［１］在人染色体９ｐ２１发现一个新的抑癌基因ｐ１６，由于该基因在多种类型肿瘤细胞株中频繁缺失，成为近年来肿瘤分子生物学的研究热点。在人原发性非小细胞肺癌中，ｐ１６基因失活被认为与肿瘤的发生密切相关［２］。作者采用免疫组化技术和ＰＣ... In 1994, Kamb et al. [1] found a new tumor suppressor gene p16 on human chromosome 9p21. Because of the frequent deletion of this gene in many types of tumor cell lines, it has become a research hotspot in molecular biology of tumors in recent years. In human primary non-small cell lung cancer, inactivation of p16 gene is considered to be closely related to tumorigenesis [2]. The authors used immunohistochemistry and PC...