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本研究用放射免疫法对各类病毒性肝病的血浆心钠素（ＡＮＦ）浓度进行了分析。结果发现：急性肝炎、慢性肝炎、肝硬化并腹水各组的血浆ＡＮＦ浓度均比对照组显著升高（Ｐ＜０．００１），特别是肝硬化并腹水组较其他各组血浆ＡＮＦ升高更为明显（Ｐ＜０．００１）。在慢性肝炎组，血浆ＡＮＦ浓度与ＩｇＧ、ＩｇＡ、ＣＩＣ之间呈显著的正相关（ｒ分别为０．４３７，０．５０７，０．６６４，Ｐ＜０．０５）。但在治疗１月前后对照的急性肝炎组、慢性肝炎组血浆ＡＮＦ浓度无显著性差别。提示各型肝病血浆ＡＮＦ浓度升高与肝实质性损害有关，在肝硬化并腹水者，则可能与心钠素的合成、贮存、释放增加，降解减少有关，但确切机理有待进一步研究。
In this study, radioimmunoassay was used to analyze plasma atrial natriuretic peptide (ANF) concentrations in various types of viral liver disease. The results showed that plasma ANF concentrations in acute hepatitis, chronic hepatitis, cirrhosis and ascites were significantly higher than those in control group (P <0.001), especially in patients with cirrhosis and ascites compared with other groups As obvious (P <0.001). In chronic hepatitis group, plasma ANF concentration was positively correlated with IgG, IgA and CIC (r = 0.437,0.507,0.664, P <0.05 respectively). However, in the control of acute hepatitis group before and after treatment in January, chronic hepatitis group plasma ANF concentration was no significant difference. It is suggested that the increase of plasma ANF concentration in all kinds of liver diseases is related to the parenchymal damage of liver. In patients with cirrhosis and ascites, it may be related to the synthesis, storage and release of atrial natriuretic peptide, and the decrease of the degradation of atrial natriuretic peptide, but the exact mechanism remains to be further studied.