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对大鼠经口给予单味葛根热水提取物(0.47/kg)及葛根汤提取剂(2g/kg),以HPLC分别鉴定了大鼠24小时的尿中代谢物。在此基础上,以同样方法对人口服单味葛根提取液及葛根汤后的尿中代谢物进行了鉴定,并对人尿中牛尿酚的代谢物进行了探讨。 结果,服用单味葛根热水提取物后,大鼠尿中出现源于葛根汤成分的5个峰(M-I～M-V)。这些峰与前报曾报告的对大鼠经口给予大豆黄甙、大豆黄素及葛根黄素后,从尿
Rats were orally administered with a single astragalus root water extract (0.47/kg) and Pueraria decoction extract (2 g/kg). Rats’ 24-hour urinary metabolites were identified by HPLC. On this basis, the urinary metabolites of the human single-pueraria puerariae extract and Pueraria decoction were identified by the same method, and the metabolites of equol in human urine were also discussed. As a result, five peaks (M-I to M-V) originating from the Puerariae soup component appeared in the urine of the rats after administration of the single-pueraria radix hot water extract. These peaks were reported in the urine after oral administration of soy bean yellow, daidzein, and puerarin to rats.