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手性联二萘基双膦配体Binap由一对2-二苯基膦萘基连接1和1’位组成,具C2-对称框架轴向手性,比旋光度达到±234°.Binap配体可以和许多过渡金属形成稳定的螯合状配合物,在催化过程中通过金属中心“传递”立体空间效应,诱导不对称催化反应.针对Binap-Ru(Ⅱ)催化体系,以体系中形成的稳定配合物为主线,详细介绍反应过程中涉及到的底物分子种类、反应条件、产物的对映选择性等以及可能的反应机理,以期对该体系有深入的理解.特别关注该体系的不对称催化应用合成.
Chiral binaphthyl bisphosphine ligand Binap by a pair of 2-diphenylphosphonaphthalene linked 1 and 1 ’bit composition, with C2-axis symmetry axial chirality, specific rotation to ± 234 ° Binap with It can form stable chelate complexes with many transition metals and induce asymmetric catalytic reactions through the metal center “transfer ” three-dimensional space effect.Aiming at the catalytic system of Binap-Ru (II) The stable complexes formed as the main line, detailing the type of substrate involved in the reaction, the reaction conditions, the enantioselectivity of the product, and possible reaction mechanism in order to have a deep understanding of the system with particular attention to the system Asymmetric Catalytic Synthesis.