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奎宁合并四环素治疗成人恶性疟有良好效果,但7岁以下儿童不能使用四环素,因此必须寻找一种新的治疗方案。近几年泰国奎宁治疗恶性疟的最低抑制浓度(MIC)已增加,而奎宁7天标准剂量不能使服药者血中奎宁浓度超过MIC达6天以上,从而达不到治愈的效果。本文研究的目的是评价改良的奎宁7天疗法的效果,并与奎宁标准剂量7天疗法和奎宁合并周效磺胺-乙胺嘧啶7天疗法两种方案进行比较。
Quinine combined with tetracycline for the treatment of adult falciparum malaria has good results, but children under the age of 7 can not use tetracycline, it is necessary to find a new treatment. In recent years, the minimum inhibitory concentration (MIC) of quinine in the treatment of P. falciparum has been increased in Thailand, while the quinine 7-day standard dose can not increase the blood quinine concentration over the MIC for more than 6 days, thus failing to achieve a curative effect. The purpose of this study was to evaluate the effect of a modified 7-day regimen of quinine compared with the quinine standard-dose 7-day regimen and quinine combined with the potent sulphate-pyrimethamine 7-day regimen.