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目的:探讨幽门螺杆菌(HP)感染对冠心病血清炎症因子指标影响。方法:选取2014年8月—2016年8月期间收治的冠心病患者138例,根据患者的HP检测结果将其分为感染组(86例)与冠心病组(52例);另选取同时期在医院进行体检的健康者64例作为对照组,比较3组患者与冠心病相关血清炎症指标,如白细胞介素-8(IL-8)、肿瘤坏死因子(TNF-α)及超敏C-反应蛋白(Hs-CRP)值的变化情况。结果:冠心病组和感染组患者冠心病血清炎症指标(IL-8、TNF-α与Hs-CRP)测得值均明显高于对照组(P<0.05);感染组患者的冠心病相关血清炎症指标测得值明显高于冠心病组(P<0.05),HP(+++)阳性感染患者中冠心病血清炎症因子指标均明显高于HP(++)阳性患者(P<0.05),而感染组HP(++)阳性患者的冠心病相关血清指标值均明显高于HP(+)阳性患者(P<0.05)。结论:HP感染的冠心病患者中,其血清中血清炎症因子指标明显高于未感染的冠心病患者,且冠心病血清炎症因子指标随HP感染程度增高而加重了症情进展。
Objective: To investigate the influence of Helicobacter pylori (HP) infection on serum inflammatory factors in patients with coronary heart disease. Methods: A total of 138 patients with coronary heart disease (CHD) were enrolled from August 2014 to August 2016. According to their HP test results, they were divided into infection group (86 cases) and coronary heart disease group (52 cases) Sixty-four healthy subjects in the hospital were selected as the control group. Serum inflammatory markers such as interleukin-8 (IL-8), tumor necrosis factor (TNF-α) and hypersensitivity C- Reactive protein (Hs-CRP) value changes. Results: The levels of serum inflammatory markers (IL-8, TNF-α and Hs-CRP) in coronary heart disease group and infection group were significantly higher than those in control group (P <0.05). The serum levels of coronary heart disease The index of inflammation index was significantly higher than that of coronary heart disease group (P <0.05). The index of serum inflammatory factors in patients with HP (+++) positive infection was significantly higher than that of HP (++) positive patients (P <0.05) Serum samples of HP (++) positive patients were significantly higher than those of HP (+) positive patients (P <0.05). CONCLUSIONS: Serum levels of serum inflammatory cytokines in patients with HP-infected CHD are significantly higher than those in patients with uninfected CHD and the severity of CHD is associated with the severity of HP infection.