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目的探讨血清降钙素原(procalcitonin,PCT)检测在诊断新生儿败血症中的作用。方法采用固相免疫层析法半定量测定新生儿败血症患儿的PCT,并与C反应蛋白(c-reactive protein,CRP)浓度及白细胞(WBC)计数作比较。结果与对照组相比,败血症患儿中PCT水平明显升高(P<0.01);三个指标中PCT阳性率最高;PCT在三个指标中的特异度、阳性预测值、阴性预测值、准确性最高。结论 PCT水平检测对早期诊断新生儿败血症具有较高的临床应用价值。
Objective To investigate the role of serum procalcitonin (PCT) in the diagnosis of neonatal sepsis. Methods Semi-quantitative determination of PCT in neonates with sepsis was performed by solid-phase immunochromatography. The PCT was compared with the C-reactive protein (CRP) and white blood cell count (WBC). Results Compared with the control group, the level of PCT in children with sepsis was significantly increased (P <0.01). The PCT positive rate among the three indicators was the highest. The specificity, positive predictive value and negative predictive value of PCT in the three indicators were accurate The highest sex. Conclusion The detection of PCT levels has a high clinical value in the early diagnosis of neonatal sepsis.