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本文针对目前临床上广泛使用的地高辛维持量疗法存在的问题,运用药物动力学的有关理论,提出了改良的负荷量疗法。文章通过血浆地高辛浓度和临床观察,比较两种疗法的临床疗效和中毒发生率。结果表明改良的地高辛负荷量疗法能提高疗效,具有减少洋地黄中毒的趋势。本文推荐的地高辛负荷量疗法为:第1天给予负荷量0.375mg～0.75mg,分2～3次服用;第2天后按Cr调整维持量。
In this paper, in order to solve the existing problems of digoxin maintenance therapy which is widely used in clinic, the improved theory of loading volume is put forward based on the theory of pharmacokinetics. Article by plasma digoxin concentration and clinical observation, comparing the clinical efficacy of both therapies and the incidence of poisoning. The results show that the modified digoxin load therapy can improve the curative effect, with the trend of reducing digitalis poisoning. This article recommended digoxin load therapy is: the first day to give the load of 0.375mg ~ 0.75mg, 2 to 3 times taken; the first 2 days to adjust the amount of maintenance by Cr.