目的　考察纳曲酮植入剂体内外药物释放的相关性 ,并比较植入动物种类和部位对植入剂体内结果的影响。方法　以聚乳酸为控释基质制备纳曲酮植入剂 ,γ 射线照射灭菌后 ,手术植入小鼠、大鼠、白兔和狗等不同动物 ,用紫外分光光度法测定体内外药物释放 ,用HPLC测定血浆和组织药物浓度。结果　不同动物及部位植入后 ,纳曲酮植入剂的体内药物释放均与体外药物释放具有良好的相关性 ,动物品种对药物释放的影响比相同动物不同植入部位的影响略大 ;单次植入给药后 ,小鼠、大鼠、白兔的体内血药浓度以及小鼠和大鼠肝、肾组织中的药物浓度和药物总量在 2 8d内保持平稳。结论　纳曲酮植入剂的体内外药物释放相关性良好 ,单次植入给药可以维持疗效 4周以上 Objective To investigate the correlation of drug release between naltrexone implant in vivo and in vitro and to compare the effects of implanting animal species and sites on the in vivo results of implants. Methods Polylactic acid was used as a controlled release matrix to prepare naltrexone implants. After γ-ray irradiation sterilization, different animals such as mice, rats, rabbits and dogs were implanted. The drug release in vitro and in vivo was determined by UV spectrophotometry The plasma and tissue drug concentrations were determined by HPLC. Results After the implantation of different animals and parts, the drug release of naltrexone implants was in good correlation with drug release in vitro. The influence of animal species on drug release was slightly greater than that of the same animals at different implantation sites. After sub-implantation, the blood concentration of mice, rats and rabbits in vivo and the concentrations of drugs and drugs in liver and kidney of mice and rats kept stable within 28 days. Conclusion Naltrexone implants have good drug release in vitro and in vivo. The single-dose administration can maintain the efficacy for more than 4 weeks