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荧光分子探针的设计、合成以及应用是分子荧光成像领域重要的化学问题.本文从Znsalen配合物的基本性质出发,概述了Znsalen配合物结构与功能的关系,特别是其发光性质与分子结构及分子聚集状态的相关性及应用.针对Znsalen配合物的发光性质,展示了其应用于分子荧光成像和活细胞中分子事件监测的研究进展.这些最新研究表明,Znsalen配合物探针的细胞毒性低(利于活细胞成像)、发光效率高(适用于单、双光子成像)、发光可调(通过配体的修饰和分子聚集状态的调节),有望作为一类重要的发光金属荧光探针实现在分子荧光成像中的应用.
The design, synthesis and application of fluorescent molecular probes are important chemical problems in the field of molecular fluorescence imaging.In this paper, based on the basic properties of Znsalen complexes, the relationship between structure and function of Znsalen complexes is summarized, especially their luminescent properties and molecular structure And the application of Znsalen complex.It is shown that the application of Znsalen complex in molecular fluorescence imaging and molecular event monitoring in living cells has shown that the cytotoxicity of Znsalen complex probe is low (For live cell imaging), high luminescence efficiency (for single and two-photon imaging) and luminescence tunable (through the modification of ligands and the regulation of molecular aggregation state) are expected to be realized as an important class of luminescent metal fluorescent probes Molecular fluorescence imaging applications.