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目的:探究胺碘酮治疗老年急性心肌梗死(AMI)伴心房颤动的疗程疗效。方法:选取于2014年1月-2016年6月来我院诊治的AMI且合并心房颤动患者74例为研究对象,采用随机数字表法分为观察组和对照组,每组各37例;观察组采用胺碘酮治疗,对照组采用毛花苷丙治疗,评价两组治疗效果,比较两组房颤动控制率、窦性心律维持率、病死率及不良反应发生率。结果:观察组的显效率、总有效率分别为73.0%(18/37)、94.6%(27/37),明显高于对照组的48.6%(27/37)、73.0%(35/37),差异有统计学意义(P=0.032,P=0.021);房颤动控制率及窦性心律维持率分别为67.6%(25/37)、81.1%(30/37)明显高于对照组的43.2%(16/37)、45.9%(17/37),差异有统计学意义(P=0.035,P=0.002);病死率及不良反应发生率分别为5.4%(2/37)、10.8%(4/37)明显低于对照组的21.6%(8/37)、51.8%(19/37),差异有统计学意义(P=0.041,P<0.001)。结论:胺碘酮治疗老年AMI伴心房颤动的临床疗效显著,药物不良反应的发生率较低,安全有效,值得在临床应用推广。
Objective: To investigate the efficacy of amiodarone in the treatment of senile acute myocardial infarction (AMI) with atrial fibrillation. Methods: From January 2014 to June 2016, 74 AMI patients with AMI complicated with atrial fibrillation in our hospital were enrolled in this study. The random number table was divided into observation group and control group, with 37 cases in each group. Group treated with amiodarone, the control group treated with curculigoside, evaluation of the two groups of treatment, compared the two groups of atrial fibrillation control rate, sinus rhythm maintenance rate, mortality and adverse reactions. Results: The effective rate and total effective rate in the observation group were 73.0% (18/37) and 94.6% (27/37) respectively, significantly higher than those in the control group (48.6%, 27/37, 73.0%, 35/37) (P = 0.032, P = 0.021). The rates of atrial fibrillation and sinus rhythm maintenance were 67.6% (25/37) and 81.1% (30/37) respectively, which were significantly higher than that of the control group (P = 0.035, P = 0.002). The incidences of mortality and adverse reactions were 5.4% (2/37) and 10.8% 4/37) was significantly lower than that of the control group (21.6%, 8/37) and 51.8% (19/37) respectively. The difference was statistically significant (P = 0.041, P <0.001). Conclusion: The clinical efficacy of amiodarone in the treatment of AMI with atrial fibrillation is significant. The incidence of adverse drug reactions is low, safe and effective, which is worth to be popularized in clinical application.