目的探讨乳腺化生性癌的临床病理特点。方法复习1例乳腺化生性癌的临床病理资料并结合文献讨论。结果该例镜下见2种高级别的肿瘤细胞成分,部分为上皮细胞巢,部分为间叶样组织,局部坏死、出血。免疫组化示肿瘤细胞ER、PR和HER-2(-);上皮细胞34βE12和AE1/AE3(+);间叶细胞vimentin、CD99和S-100(+)。结论化生性癌绝大部分为三阴性癌,侵袭性强。 Objective To investigate the clinicopathological features of mastocarcinoma. Methods To review the clinicopathological data of 1 case of metaplastic carcinoma of the breast and to discuss the literature. Results The cases of the two kinds of high-level tumor cells seen under the microscope, part of the epithelial cell nests, part of the mesenchymal tissue, local necrosis, bleeding. Immunohistochemistry showed tumor cells ER, PR and HER-2 (-); epithelial cells 34βE12 and AE1 / AE3 (+); mesenchyme vimentin, CD99 and S-100 (+). Conclusions Most of metaplastic cancers are triple-negative cancers, with strong invasiveness.