论文部分内容阅读
本文报告一例 D-青霉胺引起的晚发的硬斑病样(morphea-like)皮肤反应。1972年,一位年青时即开始有雷诺氏现象的43岁妇女患手指屈肌腱鞘炎。不久,又有腕、肩、颈、掌指及蹠趾关节的关节炎。1976年发生腕、掌指及近端指关节的滑膜炎,X 线片示有广泛的侵蚀。1977年2月开始用青霉胺治疗,每天250毫克。治疗后滑膜炎得到明显改善。治疗14个月后,患者躯干出现瘙痒性红斑,以后在腋窝、腹股沟、乳房、腹部及骨盆等处检见直径为3～10cm 大小之红斑,伴轻度表皮剥脱,某些部位呈肥厚的,有光泽的白色硬斑病样表现,无系统性硬化症之证据,亦无关节滑膜炎。
This article reports a late onset morphea-like cutaneous reaction caused by D-penicillamine. In 1972, a 43-year-old woman who had a Raynaud’s phenomenon in her youth suffered finger flexor tenosynovitis. Soon, there are wrist, shoulder, neck, palm and metatarsophalangeal joint arthritis. A wrist, a metacarpophalangeal, and synovitis of the proximal knuckles occurred in 1976, and X-rays showed extensive erosion. Beginning in February 1977 with penicillamine treatment, 250 mg per day. After treatment, synovitis was significantly improved. After 14 months of treatment, the patient presented with pruritic erythema in the trunk. Later, erythema with a diameter of 3 to 10 cm was detected in the armpits, groin, breast, abdomen and pelvis, with slight exfoliation of the epidermis, hypertrophy in some areas, Shiny white scleroid disease-like performance, no evidence of systemic sclerosis, nor synovitis.