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目的 探讨一氧化氮与梗阻性黄疸门静脉高压的关系以及早期胆肠内引流对其影响。方法 通过大鼠胆总管结扎及胆肠内引流模型 ,测定血浆一氧化氮水平及门静脉压力 ,并分析二者关系。结果 大白鼠胆总管结扎 2周后 ,门静脉压力及血浆硝酸盐含量较对照组明显升高 ,胆肠内引流术后门静脉压力及血浆硝酸盐含量较胆总管结扎组明显降低 ,血浆硝酸盐水平与门静脉压力呈正相关。结论 一氧化氮在梗阻性黄疸门静脉高压的发病机制中具有重要作用 ;早期胆肠内引流能减少一氧化氮的产生 ,降低门静脉压力。
Objective To investigate the relationship between nitric oxide and portal hypertension caused by obstructive jaundice and the effect of early enteral drainage on it. Methods The rat model of bile duct ligation and bile duct drainage was used to determine plasma nitric oxide level and portal vein pressure. The relationship between them was analyzed. Results After two weeks of common bile duct ligation in rats, portal pressure and plasma nitric oxide levels were significantly higher than those in the control group. The portal pressure and plasma nitric oxide levels were significantly lower in the biliary than in the common bile duct ligation group. The levels of plasma nitrate Portal pressure was positively correlated. Conclusion Nitric oxide plays an important role in the pathogenesis of portal hypertension in obstructive jaundice. Early drainage of bile duct can reduce the production of nitric oxide and decrease the pressure of portal vein.