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目的探讨鼻塞式持续气道正压通气(nCPAP)联合氨溴索治疗早产儿呼吸窘迫综合症的疗效及预后观察、随访结果。方法所有病例均来自我院2006年5月-2009年8月新生儿重症监护室(NICU)住院患儿,在保暖、清理呼吸道、保持呼吸道畅通、防治感染、预防出血等常规治疗同时,给予氨溴索联合治疗,窘迫症状不缓解及时给予nCPAP治疗。结果35例呼吸窘迫患儿中,有效28例,放弃治疗2例,4例死亡。成活患儿临床随访,中度贫血15例,重度贫血3例,给予输血治疗好转。余无严重后遗症发生。结论nCPAP联合氨溴索治疗可提高早产儿呼吸窘迫综合症的成活率和预后,尤其在经济不发达地区,没有呼吸机及肺泡表面活性物质(PS),在抢救早产儿呼吸窘迫综合症时值得临床借鉴。
Objective To investigate the efficacy and prognosis of nasal continuous positive airway pressure (nCPAP) combined with ambroxol in the treatment of respiratory distress syndrome in preterm infants and the follow-up results. Methods All patients were from our hospital From May 2006 to August 2009 neonatal intensive care unit (NICU) hospitalized children, in the warm, clean the respiratory tract, keep the airway open, prevent infection, prevent bleeding and other conventional treatment given ammonia Bromine combined treatment, distress symptoms do not relieve promptly given nCPAP treatment. Results Of the 35 children with respiratory distress, 28 were effective, 2 were given up and 4 died. Survival of children with clinical follow-up, 15 cases of moderate anemia, severe anemia in 3 cases, give blood transfusion improved. I have no serious sequelae. Conclusions nCPAP combined with ambroxol can improve the survival rate and prognosis of respiratory distress syndrome in preterm infants, especially in economically underdeveloped areas, without ventilator and alveolar surfactant (PS), and worthwhile in the rescue of respiratory distress syndrome in premature infants Clinical reference.