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目的探讨Ph染色体阳性青少年急性淋巴细胞白血病(Ph+ALL)NICM分型对临床治疗和预后的指导意义。方法采用KaplanMeier法进行生存分析,同时采用COS回归模型进行多因素预后分析。结果Ph+ALL占青少年ALL的18.37%(9/49)。与Ph-ALL患者相比,Ph+ALL患者白细胞计数高,同时伴有髓系抗原表达者明显增多,完全缓解率低,第一次缓解中位时间长。Ph+ALL的复发率高于Ph-ALL,3年预期DFS率低于Ph-ALL。结论Ph+ALL是一种预后不良的细胞遗伟学亚型,具有独特的生物学、临床和预后特征,治疗上应用别与Ph-ALL。
Objective To investigate the clinical significance of Ph + ALL NICM typing in clinical treatment and prognosis of Ph chromosome-positive juvenile acute lymphoblastic leukemia. Methods Survival analysis was performed by Kaplan Meier method and multivariate prognostic analysis was performed by using COS regression model. Results Ph + ALL accounted for 18.37% (9/49) of adolescents with ALL. Ph + ALL patients compared with high white blood cell count, accompanied by a significant increase in myeloid antigen expression, complete remission rate was low, the first median long-term relief. The recurrence rate of Ph + ALL is higher than that of Ph-ALL, and the expected DFS rate at 3 years is lower than that of Ph-ALL. Conclusion Ph + ALL is a poor prognostic subtype of cytogenetics with unique biological, clinical and prognostic features.