论文部分内容阅读
目的探讨硫普罗宁联合甘草酸二铵注射液治疗慢性病毒性乙型肝炎的临床疗效。方法选取2013年12月—2015年1月广西南宁市邕宁区人民医院收治的慢性病毒性乙型肝炎患者140例,按照住院先后顺序分为治疗组与对照组,各70例。对照组患者予以甘草酸二铵注射液治疗,治疗组患者在对照组基础上加用硫普罗宁治疗。观察两组患者治疗15、30d肝功能指标复常率(血清丙氨酸氨基转移酶复常率、胆红素复常率)、乙肝标志物〔乙肝病毒脱氧核糖核酸(HBV-DNA)、乙肝病毒e抗原(HBe Ag)、乙肝表面抗原(HBs Ag)〕转阴情况、临床疗效及不良反应发生情况。结果治疗15d两组患者血清丙氨酸氨基转移酶复常率、胆红素复常率比较,差异无统计学意义(P>0.05);治疗30d治疗组血清丙氨酸氨基转移酶复常率、胆红素复常率高于对照组,差异有统计学意义(P<0.05)。两组患者HBV-DNA、HBe Ag、HBs Ag转阴率比较,差异无统计学意义(P>0.05)。治疗组患者总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者均未发生严重不良反应。结论硫普罗宁联合甘草酸二铵注射液治疗慢性病毒性乙型肝炎的临床疗效显著,可改善患者临床症状,且不良反应少。
Objective To investigate the clinical efficacy of tiopronin combined with diammonium glycyrrhizinate injection in the treatment of chronic viral hepatitis B. Methods From December 2013 to January 2015, 140 cases of chronic viral hepatitis B patients admitted to Suining People’s Hospital of Nanning City, Guangxi Province were divided into treatment group and control group according to the order of hospitalization, with 70 cases each. Patients in the control group were treated with diammonium glycyrrhizinate injection. The patients in the treatment group were treated with tiopronin on the basis of the control group. The normalization rate of liver function index (serum alanine aminotransferase normalization rate, bilirubin recovery rate), hepatitis B virus markers (HBV-DNA, hepatitis B Virus e antigen (HBe Ag), hepatitis B surface antigen (HBs Ag)〕 negative situation, clinical efficacy and adverse reactions. Results There was no significant difference in the normalization rate of serum alanine aminotransferase and bilirubin recovery between the two groups on the 15th day after treatment (P> 0.05). The normalization rate of serum alanine aminotransferase , Bilirubin normalization rate was higher than the control group, the difference was statistically significant (P <0.05). There was no significant difference in the negative conversion rate of HBV-DNA, HBeAg and HBsAg between the two groups (P> 0.05). The total effective rate of the treatment group was higher than that of the control group, the difference was statistically significant (P <0.05). No serious adverse reactions occurred in both groups. Conclusion The combination of tiopronin and diammonium glycyrrhizinate for the treatment of chronic viral hepatitis B has significant clinical effect, which can improve the clinical symptoms of patients with less adverse reactions.