观察锦红片对急性胆道感染时细胞因子的调节和肠黏膜屏障保护作用的机理。建立SD大鼠急性胆管炎模型 ,分为模型组、锦红片治疗组、抗生素治疗组、单纯结扎组与假手术组 ,观察血生化、细胞因子、炎症介质、病理、细菌移位等指标。结果 :锦红片能有效地抑制肠道细菌的移位 ,对抗内毒素血症 ,并有显著降低血清胆红素 ,减轻急性胆道感染对肝肾损伤的作用 ,能保持细胞因子和炎症介质在急性炎症反应时的相对稳定 ,抑制过度的炎症反应 ,维持机体免疫功能的平衡。提示锦红片在治疗急性胆道感染中具有调节机体免疫和保护肠黏膜屏障的作用观察锦红片对急性胆道感染时细胞因子的调节和肠黏膜屏障保护作用的机理。建立SD大鼠急性胆管炎模型 ,分为模型组、锦红片治疗组、抗生素治疗组、单纯结扎组与假手术组 ,观察血生化、细胞因子、炎症介质、病理、细菌移位等指标。结果 :锦红片能有效地抑制肠道细菌的移位 ,对抗内毒素血症 ,并有显著降低血清胆红素 ,减轻急性胆道感染对肝肾损伤的作用 ,能保持细胞因子和炎症介质在急性炎症反应时的相对稳定 ,抑制过度的炎症反应 ,维持机体免疫功能的平衡。提示锦红片在治疗急性胆道感染中具有调节机体免疫和保护肠黏膜屏障的作用 Observe the mechanism of the protective effect of Jinhong Tablets on cytokine regulation and intestinal mucosal barrier during acute biliary tract infection. SD rat acute cholangitis model was established and divided into model group, Jinhong tablet treatment group, antibiotic treatment group, simple ligation group, and sham operation group. Blood biochemistry, cytokines, inflammatory mediators, pathology, and bacterial translocation were observed. RESULTS: Jinhong Tablets can effectively inhibit the translocation of intestinal bacteria, combat endotoxemia, and significantly reduce serum bilirubin, reduce the effect of acute biliary tract infection on liver and kidney damage, and can maintain cytokine and inflammatory mediators. The acute inflammatory response is relatively stable, suppresses excessive inflammatory responses, and maintains the balance of immune function. It is suggested that Jinhong Tablets have the function of regulating the immune system and protecting the intestinal mucosal barrier in the treatment of acute biliary tract infection. To observe the mechanism of the protective effect of Jinhong Tablet on cytokines and intestinal mucosal barrier in acute biliary tract infection. SD rat acute cholangitis model was established and divided into model group, Jinhong tablet treatment group, antibiotic treatment group, simple ligation group, and sham operation group. Blood biochemistry, cytokines, inflammatory mediators, pathology, and bacterial translocation were observed. RESULTS: Jinhong Tablets can effectively inhibit the translocation of intestinal bacteria, combat endotoxemia, and significantly reduce serum bilirubin, reduce the effect of acute biliary tract infection on liver and kidney damage, and can maintain cytokine and inflammatory mediators. The acute inflammatory response is relatively stable, suppresses excessive inflammatory responses, and maintains the balance of immune function. Tips Jinhong Tablets have the function of regulating the immune system and protecting the intestinal mucosal barrier in the treatment of acute biliary tract infections