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肺间质纤维化是引起各种慢性肺疾病进展至终末期呼吸衰竭的共同病理特征之一[1]。肺间质纤维化细胞活化增殖、细胞外基质(extracellular matrixc,ECM)大量沉积是直接原因。尽管引起肺间质细胞的激活和ECM沉积的确切机制尚未完全明了,但一些生长因子与细胞因子活性变化与纤维化细胞和ECM代谢调节呈显著相关。转化生长因子-β(transforming growth factor-β,TGF-β)是公认的纤维化产生和发展的关键性细胞因子[2]。慢性肺脏病变有许多组织结构的变化可以理解为由TGF-β诱导所致,但有一
Pulmonary interstitial fibrosis is one of the common pathological features that cause various chronic lung diseases to progress to end-stage respiratory failure [1]. Proliferation and proliferation of pulmonary interstitial fibrosis cells, extracellular matrix (ECM) mass deposition is the direct cause. Although the precise mechanisms that cause pulmonary interstitial activation and ECM deposition are not fully understood, some changes in growth factor and cytokine activity are significantly associated with metabolic regulation of fibrotic cells and ECM. Transforming growth factor-β (TGF-β) is a recognized key factor in the development and progression of fibrosis [2]. There are many changes in the histological structure of chronic lung disease can be understood as induced by TGF-β, but there is a