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本文通过卵巢粘液性囊腺癌伴肉瘤样附壁结节,卵巢粘液性囊腺癌伴局限性间变癌和卵巢癌肉瘤各1例的形态学和免疫组织化学研究,讨论其鉴别诊断。三种不同性质的肿瘤大体均以卵巢囊性肿瘤伴实性附壁结节的形式出现,组织学形态也十分相似。但肉瘤样附壁结节无浸润性边缘,核分裂数≤10个/10HPF,免疫标记KP-1阳性。间变性癌有浸润性边缘,和囊肿上皮间有移行,间质胶原反应较明显,免疫标记EMA或Cytokeratin阳性。卵巢真正的肉瘤也有浸润性边缘,和上皮成分相互渗透,核分裂数>10个/10HPF,免疫标记KP-1阴性,但Vimentin阳性。
This article through the ovarian mucinous cystadenocarcinoma with sarcomatoid-like adherent nodules, ovarian mucinous cystadenocarcinoma with confinement of cancer and ovarian sarcoma in 1 case of morphological and immunohistochemical studies to discuss the differential diagnosis. Three different types of tumors are mostly ovarian cysts with solid appendage nodules in the form of histological morphology is also very similar. However, sarcomatoid non-invasive infiltration of mural nodules edge, mitotic number ≤ 10 / 10HPF, immune markers KP-1 positive. Anaplastic carcinoma with invasive margin, and cyst epithelial migration, interstitial collagen reaction was more obvious, immunohistochemical EMA or Cytokeratin positive. True ovarian sarcoma also has infiltrating margins, and epithelial components of mutual penetration, mitotic numbers> 10 / 10HPF, immunophenotype KP-1 negative, but Vimentin positive.