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自从1868年Paul Langerhans发现郎格罕细胞(LC)以来,研究主要集中在皮肤和粘膜LC的识别及其免疫功能上。1984年,Volc-Platzer和Perrault等在骨髓移植后,肯定了人类LC来源于骨髓,并进一步发现在移植早期,几乎所有患者都严重缺乏LC。1986年,Guyotat等人在2例自体移植患者中也发现了同样现象,因此认为LC的改变是受部位条件的影响。体外研究证实,有一小部分CD_1~+细胞表达骨髓前单核
Since the discovery of Langerhans cells (LC) by Paul Langerhans in 1868, research has focused on the identification of the cutaneous and mucosal LCs and their immune function. In 1984, Volc-Platzer and Perrault confirmed that human LC was derived from bone marrow after bone marrow transplantation, and further found that in the early stages of transplantation, almost all patients are severely deficient in LC. In 1986, Guyotat et al. Found the same phenomenon in 2 cases of autograft patients. Therefore, it is considered that the change of LC is affected by site conditions. In vitro studies confirm that a small percentage of CD_1 ~ + cells express pre-myeloid mononuclear cells