目的　探讨营养不良、肾病本身和糖皮质激素作为各自独立因素对大鼠血清生长激素结合蛋白（ＧＨＢＰ）及肝脏生长激素受体（ＧＨＲ）表达的影响，阐明ＧＨＢＰ／ＧＨＲ改变与肾病综合征（ＮＳ）大鼠生长障碍的关系。方法　２４只周龄相同体重相近的雄性ＳＤ大鼠被随机分成正常、食物对照、阿霉素（５ｍｇ· ｋｇ）肾病和地塞米松（１．８ ｍｇ· ｋｇ－１· ｄ－１）治疗的阿霉素肾病４组。血清 ＧＨＢＰ、ＧＨＢＰ－１浓度及肝脏ＧＨＲ表达分别采用墨炭包被的葡聚糖蛋白分裂技术、凝胶层析和放射受体分析法检测。结果１．和正常及食物对照组大鼠相比，肾病和激素治疗组血清ＧＨＢＰ和肝脏ＧＨＲ的减低其差异有显著性意义，但食物对照组较正常组，激素治疗组较肾病组之减低，其差异无显著意义。２．血清ＧＨＢＰ－１浓度依正常、食物对照、肾病和激素治疗组顺序逐一减低。３．血清ＧＨＢＰ浓度及肝脏ＧＨＲ表达与大鼠鼻尾长度和体重均呈正相关（Ｐ均＜０．０１）。结论继发性营养不良和肾病本身所致的生长障碍与肝脏ＧＨＲ表达下降引发的生长激素抵抗有关，糖皮质激素治疗后生长激素抵抗加重也是其生长障碍加剧的重要因素。 Objective To investigate the effects of malnutrition, nephropathy and glucocorticoids on the expression of serum growth hormone binding protein (GHBP) and growth hormone receptor (GHR) in rats, and to elucidate the relationship between GHBP / GHR changes and nephrotic syndrome ) Growth disorders in rats. Methods Twenty-four male Sprague-Dawley rats of similar body weight at the same age were randomly divided into normal control group, nephropathy treated with doxorubicin (5 mg · kg) and dexamethasone (1.8 mg · kg-1 · d-1) Adriamycin nephropathy 4 groups. Serum GHBP, GHBP-1 concentration and liver GHR expression were detected by dextran-coated dextran protein cleavage technique, gel chromatography and radioimmunoassay. Results 1. Compared with normal and food control rats, the differences of serum GHBP and GHR in kidney disease and hormone therapy group were significant, but the food control group was lower than the normal group and the hormone therapy group than the nephropathy group, the difference was not Significant. 2. Serum GHBP-1 concentration by normal, food control, kidney disease and hormone treatment group one by one reduce the order. 3. Serum GHBP concentration and liver GHR expression were positively correlated with the length and weight of rat’s nose and tail (P <0.01). CONCLUSIONS: Secondary malnutrition and growth disorders due to nephropathy are associated with growth hormone resistance induced by decreased expression of GHR in the liver. Increased GHR after glucocorticoid therapy is also an important factor in aggravating growth disorders.