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异三尖杉酯碱(1)为三尖杉属植物所含具有抗肿瘤活性的四种酯碱之一,其本身的合成已有三种不同的方法先后获得成功。据报道,异三尖杉酯碱(1)能明显延长患白血病L615的小鼠的生命,而异三尖杉酯碱酸(2)却无效。这一结果说明侧链酯基的存在是这类化合物具
Homoharringtonine (1) is one of the four ester bases with anti-tumor activity contained in Cephalotaxus. Three different methods have been developed for their success. It has been reported that homoharringtonine (1) significantly prolongs the life of mice with leukemia L615, whereas homoharringtonine (2) is not effective. This result shows that the presence of pendant ester groups is of this type