对培养人眼视网膜色素上皮（ＲＰＥ）细胞磷酸肌醇（ＩｎｓＰｓ）水平的分析表明，Ｃａｒｂａｃｈｏｌ显著刺激ＲＰＥ细胞ＩｎｓＰｓ水平的升高，且该效应可被阿托品所阻断，表明在入眼ＲＰＥ细胞存在毒蕈碱受体。去甲肾上腺素、５－羟色胺、表皮生长因子（ＥＧＦ）、异丙肾上腺素、和ＮＥＣＡ对ＩｎｓＰｓ基础水平无明显影响。异丙肾上腺素和ＮＥＣＡ对Ｃａｒｂａｃｈｏｌ刺激ＩｎｑＰｓ的效应也无明显影响；但ＥＧＦ显著促进Ｃａｒｂａｃｏｌ刺激人眼ＲＰＥ细胞ＩｎｘＰｓ，水平升高的效应。提示在人眼ＲＰＥ细胞ＥＧＦ与毒章碱受体之间存在有受体间交互作用。 Analysis of the levels of InsPs in cultured human retinal pigment epithelium (RPE) cells showed that Carbachol significantly stimulated the increase of InsPs levels in RPE cells and this effect could be blocked by atropine, indicating that there is toxicity in the target RPE cells Muscarinic receptors. Norepinephrine, serotonin, epidermal growth factor (EGF), isoproterenol, and NECA had no significant effect on the basal levels of InsPs. Isoproterenol and NECA also had no significant effect on Carbachol-stimulated InqPs; however, EGF significantly promoted the effect of Carbacol on InxPs and the level of human RPE cells. It is suggested that there is an inter-receptor interaction between human eye RPE cells EGF and the drug of canonical alkali.