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用体外放射性配体结合实验方法检测了梭曼对牛小脑γ-氨基丁酸(GABA)受体和GABA摄取的影响.10~(-3)～10~(-6)M未影响GABA受体结合;对GABA摄取有轻微抑制IC_(50)为1.4×10~(-3)M.这一结果未能支持加拿大学者Lundy关于梭曼中毒有可能影响GABA受体结合的假设.对梭曼中毒与GABA系统的关系进行了讨论.
The effects of soman on GABA receptor and GABA uptake in the cerebellum were detected by in vitro radioligand binding assay.10 ~ (-3) -10 ~ (-6) M did not affect GABA receptor , And a slight inhibition of GABA uptake was found to be 1.4 × 10 ~ (-3) M. This result failed to support the hypothesis of Canadian scholar Lundy that somatotoxicity may affect GABA receptor binding. The relationship with the GABA system is discussed.