作者研究了72份冷球蛋白血症病历,均有皮损活检标本和血清冷球蛋白实验资料。72例患者(女∶男为1.3∶1)年龄26～82岁,其中Ⅰ型12例(17%),Ⅱ型37例(51%),Ⅲ型10例(14%),未定类型13例(18%)。48例(67%)患者无基础疾病,14例(19%)有淋巴增生性疾病,10例(14%)有胶原血管性疾病。最常见的系统表现有肾病(20例,28%)、高血压(13例,18%)、神经系统疾病(13例,18%)和肝病(6例,8%)。临床表现:皮损有疼痛、触痛,15例有 The authors studied 72 cryoglobulinemic medical records, both skin biopsy specimens and serum cryoglobulin experimental data. 72 patients (female: male 1.3: 1) were 26-82 years old, including 12 cases of type I (17%), 37 cases of type II (51%), 10 cases of type III (14%), 13 cases of undetermined type (18%). Forty-eight patients (67%) had no underlying disease, 14 (19%) had lymphoproliferative disease and 10 (14%) had collagen-induced vascular disease. The most common systemic manifestations were nephropathy (20 cases, 28%), hypertension (13 cases, 18%), neurological disease (13 cases, 18%) and liver disease (6 cases, 8%). Clinical manifestations: skin lesions have pain, tenderness, 15 cases have