目的：探讨定量检测血清抗甲状腺球蛋白抗体（TG-Ab）和抗甲状腺过氧化物酶抗体（TPO-Ab）在自身免疫性甲状腺疾病诊断中的作用。方法用电化学发光方法检测不同甲状腺疾病患者血清抗甲状腺球蛋白抗体（TG-Ab）、抗甲状腺过氧化物酶抗体（TPO-Ab）水平，比较不同甲状腺疾病患者及正常对照组之间TG-Ab、TPO-Ab水平的差异。结果血清TG-Ab、TPO-Ab在不同甲状腺自身免疫性疾病中水平不一。结论 TG-Ab、TPO-Ab定量检测可帮助甲状腺自身免疫性疾病的诊断及鉴别诊断。“,”Obiective To investigate the role of the serum anti thyroglobulin antibody (TG-Ab) and anti thyroid peroxidase antibody (TPO-Ab) in diagnosis of different kinds of autoimmune thyroid diseases. Methods The levels of TG-Ab and TPO-Ab were tested in different kinds of autoimmune thyroid diseases by using electrochemical luminescence methods and then we compared the levels of TG-Ab and TPO-Ab among different groups. Conclusion Different autoimmune thyroid diseases showed different levels of TG-Ab and TPO-Ab significantly. It suggests that quantitative detection of TG-Ab and TPO-Ab can help diagnosis and differential diagnosis.