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目的:比较两种方案治疗消化性溃疡出血的疗效、不良反应并运用药物经济学原理进行评价。方法: 90例患者随机分成两组,治疗组静脉滴注国产泮托拉唑,对照组静滴进口奥美拉唑,比较其疗效及成本。结果:用药3d,总有效率分别为治疗组84.78%、对照组81.82%,差异无显著性(P>0.05),治疗成本分别为治疗组(1 084.43±247.38)元、对照组(1 121.23±275.95)元,差异有统计学意义(P<0.05);用药5d,总有效率分别为治疗组95.65%、对照组93.18%(p>0.05),治疗成本分别为治疗组(1 270.45±218.12)元、对照组(1 407.51±351.01)元(P<0.05)。结论:以最小成本法评价,治疗组的方案为2种方案中的优选方案。
OBJECTIVE: To compare the efficacy of the two regimens in the treatment of peptic ulcer bleeding and the adverse reactions and to evaluate the principles of pharmacoeconomics. Methods: Ninety patients were randomly divided into two groups. The treatment group was given intravenous pantoprazole intravenously and the control group was orally administered omeprazole. The efficacy and cost were compared. Results: The total effective rate was 84.78% in the treatment group and 81.82% in the control group, respectively, with no significant difference (P> 0.05) after 3 days of treatment. The treatment costs were respectively 1 084.43 ± 247.38 yuan and 1 121.23 ± The total effective rate was 95.65% in the treatment group and 93.18% in the control group respectively (p> 0.05), and the treatment costs were respectively treatment group (1 270.45 ± 218.12) Yuan and control group (1 407.51 ± 351.01) yuan (P <0.05). CONCLUSIONS: The minimal cost method was used to evaluate the treatment regimen as the preferred regimen among the two regimens.