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目的探讨肿瘤标志物对肺癌的诊断价值。方法选取2013年12月—2016年5月连云港市赣榆区人民医院收治的肺癌患者50例作为肺癌组,肺部良性病变患者50例作为良性病变组,健康体检者50例作为对照组。检测并比较3组受试者细胞角蛋白21-1片段(CYFRA21-1)、癌胚抗原(CEA)、神经元神经特异性烯醇化酶(NSE)、糖类抗原125(CA125)及胃泌素释放肽前体(Pro-GRP)水平,并分析其对肺癌的诊断价值。结果肺癌组患者CYFRA21-1、CEA、NSE、CA125、Pro-GRP水平高于良性病变组、对照组,良性病变组患者CYFRA21-1、Pro-GRP水平高于对照组(P<0.05)。CYFRA21-1诊断肺癌的灵敏度、阳性预测值及有效性高于其他肿瘤标志物(P<0.05)。结论肿瘤标志物对肺癌的诊断价值较高,其中以CYFRA21-1诊断肺癌的灵敏度最高。
Objective To investigate the diagnostic value of tumor markers in lung cancer. Methods Fifty patients with lung cancer who were admitted to the Ganyu People’s Hospital of Lianyungang City from December 2013 to May 2016 were selected as the lung cancer group, 50 patients with benign lung disease as the benign lesion group and 50 healthy subjects as the control group. The levels of cytokeratin 21-1, CEA, NSE, carbohydrate antigen 125 (CA125) and gastric secretion (Pro-GRP) levels, and analysis of its diagnostic value of lung cancer. Results The levels of CYFRA21-1, CEA, NSE, CA125 and Pro-GRP in patients with lung cancer were significantly higher than those in patients with benign disease, controls and benign lesions (P <0.05). The sensitivity, positive predictive value and effectiveness of CYFRA21-1 in diagnosing lung cancer were higher than those of other tumor markers (P <0.05). Conclusion Tumor markers have a higher diagnostic value for lung cancer, of which CYFRA21-1 has the highest sensitivity for the diagnosis of lung cancer.