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盐酸特比萘芬(Terbinafine Hydrochloride,TBF)是在萘替芬的基础上发展起来的新一代丙烯胺类抗真菌药。本品抗菌谱广,抗真菌活性高,其作用机理为高选择性地抑制真菌角鲨烯环氧化酶,使真菌细胞膜形成过程中角鲨烯环氧化反应受阻,从而达到杀灭或抑制真菌的作用,临床对手足癣和体股癣治愈率达80～90％。目前本品的软膏剂、片剂国内已经上市,我厂研制开发了其散剂剂型,经临床验证,具有疗效好、安全性高、使用舒适方便的特点,现报道如下:
Terbinafine Hydrochloride (TBF) is a new generation of allylamine antifungal agent developed on the basis of naftifine. This product broad antibacterial spectrum, high antifungal activity, its mechanism of action is highly selective inhibition of fungal squalene cyclooxygenase, the fungal cell membrane during the formation of squalene epoxidation blocked, so as to kill or inhibit The role of fungi, clinical opponents Tinea pedis and body tinea corporis cure rate of 80 to 90%. At present, this product ointment, tablet has been listed, I plant developed its powder formulations, clinically proven, with good efficacy, high safety, comfort and convenience of use, are reported as follows: